<i id='A53777042B'><strike id='A53777042B'><tt id='A53777042B'><time date-time="084b35"></time><tt dir="6db5f5"></tt><var lang="6a98fd"></var><pre date-time="ee8c9c" id='A53777042B'></pre></tt></strike></i> By Lisa J Hackett, Huw Nolan and Jo Coghlan* of 
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